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This presentation explores the catastrophic Columbia disaster, detailing the causes that led to the tragic loss of seven astronauts. It discusses the failure of the thermal protection system due to foam insulation and highlights NASA's response and corrective actions taken afterward. The analysis stresses the importance of recognizing risks and the human factors contributing to the oversight in mission management.

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The Chandrayaan-3 mission significantly advances India's lunar exploration. It focuses on in-situ observations, including elemental composition and thermal profiling of the lunar regolith. The successful soft landing at high lunar latitudes provides unique data opportunities, while the mission showcases advancements in technology and science from previous missions, paving the way for future lunar exploration.

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This presentation explores how inflammatory indices, particularly the weighted summary score (WSS), correlate with the incidence of postoperative delirium in adults over 70 undergoing noncardiac surgery. By analyzing multiple inflammatory biomarkers, the study reveals significant associations suggesting that aggregated data may provide better predictive insights compared to individual markers.

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This presentation explores recent significant policy reversals regarding the Covid mRNA vaccines in large healthcare systems, including the Ohio State University Medical Center. It discusses the alarming reports of staff illnesses, increasing lawsuits, and internal changes around vaccine administration, raising ethical concerns about patient and employee safety amid shifting public health guidelines.

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This analysis raises urgent concerns regarding the FDA's approval of at-home administration of the FluMist nasal vaccine, highlighting the public health risks posed to immunocompromised populations. Issues include increased exposure to live viral particles and neurological risks from improper administration. Stringent regulations are needed to safeguard vulnerable communities amid these oversight gaps.

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Recent research reveals that the Step Pyramid of Djoser may have been constructed using sophisticated hydraulic lift systems powered by nearby canals. This revolutionary method contrasts with earlier beliefs that ramps and levers were primarily used. The study opens a new line of inquiry into ancient construction techniques and highlights the remarkable engineering skills of the Egyptians.

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Dr. Drew Pinsky explores the ongoing challenges facing the physician-patient relationship amid the opioid crisis and COVID-19. He critiques how centralized medical practices hinder personal care, emphasizing the need for a collaborative and patient-focused approach. He reflects on the historical parallels of medical responses during crises and the erosion of ethical standards in patient treatment.

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This presentation explores the evolution of biomarkers associated with biological age, emphasizing DNA methylation's role in shaping our understanding of ageing. It discusses the establishment of epigenetic clocks, their predictive accuracy across tissues, and their implications for healthspan and lifespan interventions. The mechanisms and related cultural shifts in science are also examined.

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This study analyzes the relationship between COVID-19 vaccinations and the incidence of cerebral thrombotic events. By systematically comparing adverse event reports from the CDC’s VAERS database, the research reveals a significantly higher prevalence of cerebral venous thrombosis in vaccinated individuals compared to those vaccinated with influenza or other vaccines, indicating serious safety concerns.

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Is Uri Geller the world's most gifted psychic, capable of bending metal without touching it and discovering the contents of closed boxes with incredible accuracy? Or is he the biggest hoaxer of our time, able to convince trained scientists that they saw things which never actually happened? This week, Mature publishes the first scientific paper on Geller-a report on tests at the Stanford Research Institute. And in this special issue of New Scientist, Dr Joseph Manion reports.

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This presentation challenges the conventional wisdom surrounding chemotherapy, highlighting its potential to exacerbate cancer progression. It explores how chemotherapy can trigger stress responses in cancer cells, disrupt the tumor microenvironment, and enhance cancer cell survival, making it a questionable treatment option as evidence mounts against its effectiveness in cancer care.

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This presentation explores the complexities of diagnosing and managing Borderline Personality Disorder (BPD). It highlights the importance of accurate diagnosis, evidence-based treatment strategies, and understanding the interplay of neurobiological and psychodynamic factors. Clinicians will gain insights to improve patient outcomes and navigate the ongoing debates surrounding BPD's validity as a distinct disorder.

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This presentation dives into the four key aspects of personality: extraversion/introversion, neuroticism/stability, openness/closedness, and conscientiousness. Each dimension significantly impacts individual behavior and decision-making in the business world. Understanding these traits can enhance management strategies, improve teamwork, and foster personal growth within organizations. Discover how personality shapes our interactions.

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Research indicates that cannabis use exacerbates brain connectivity deficits in young adults at risk for psychosis. A study from McGill University found reduced synaptic density linked to social withdrawal and motivational issues, highlighting the need for targeted therapies. These findings could revolutionize psychosis treatment by focusing on previously neglected symptoms rather than just hallucinations.

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Cardiac disease is a leading cause of death worldwide. As more people survive heart attacks, there’s a pressing need to enhance cardiac rehabilitation services. Professor Julie Redfern aims to modernize these programs through global collaboration, ensuring better healthcare access and preventive strategies for survivors to manage their ongoing heart health effectively.

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Dr. Johanna Olson-Kennedy, a prominent figure in youth gender medicine, faces a medical-negligence lawsuit from former patient Clementine Breen. Breen alleges harm from a lack of proper psychological assessment before her transition treatments, including puberty blockers and a double mastectomy at age 14. This case highlights critical debates over mental-health protocols in youth gender services amid increasing scrutiny and legal challenges.

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This presentation reviews recent advances in the understanding of Posttraumatic Stress Disorder (PTSD), discussing its pathophysiology, diagnosis, and evidence-based management. Highlights include the exploration of neurobiological underpinnings, symptomatology, and effective personalized and phase-specific interventions essential for improving patient outcomes.

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This study analyses changes in sexual behavior, specifically penile-vaginal intercourse (PVI) frequency and sexual repertoire, using data from the National Survey of Sexual Health and Behavior conducted in 2009 and 2018. The findings indicate a decline in PVI for both adolescents and adults, suggesting shifts in how sexual intimacy is experienced and reported.

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This study investigates the serum levels of zinc and magnesium in type-2 diabetic patients compared to healthy controls. It explores associations with age, gender, glycemic status, and diabetes duration, revealing significant findings about zinc deficiency without notable magnesium differences, contributing valuable insights into diabetes management and nutritional requirements.

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This presentation reviews a rare case of brain death linked to nicotine intoxication following the ingestion of e-cigarette liquid. It explores the neurological impact, regulatory implications, and the mechanisms behind nicotine toxicity, emphasizing the importance of understanding public health risks associated with e-cigarettes.

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Explore the Chernobyl disaster's timeline, its devastating impact on human health, and environmental changes. Learn the causes behind the reactor explosion, the response efforts, and ongoing repercussions for Ukraine, including economic costs and ecological recovery. This presentation highlights Chernobyl's historical significance and lessons for future nuclear safety.

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This impact report presents achievements from Cycle 1 of the Rare As One Network, a network of 94 patient-led rare disease organizations driving forward progress against rare disease. This report highlights the scientific momentum and progress these organizations have inspired, and the impact that a network of similarly placed and determined patient advocates can have when provided with baseline funding, capacity building support and opportunities to collaborate with one another.

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This presentation discusses the critical need for an effective pandemic surveillance system, emphasizing wastewater biosensors as a key tool for early detection. By integrating these sensors into local communities, we can achieve real-time data collection and improve public policy decisions, ultimately enhancing our preparedness for future pandemics. The approach is scalable, reusable, and eco-friendly, ensuring sustainable monitoring.

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Presentation from Dr. Fatma Dedeoglu: Weaning Therapy

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Presentation from Dr. Bas Vastert: Biomarker-Guided Treatment-And-Stop_Strategy for Recombinat IL-1Receptor Antagonist (anakinra) in systemic Juvenile Idiopathic Arthritis

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Presentation from Dr. Michael Ombrello: What is the role of HLA DRB1*15 in Still's disease

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Presentation from Dr. Mariana Marques: Recent discovery in genomics of SJIA

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Presentation from Dr. Randy Cron: Clinical Utility of Genetics in systemic JIA

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Presentation from Dr. Lauren Henderson: recognizing and Treating Lung Disease in Systemic Juvenile idiophatic Arthritis

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Presentation from Dr. Claudia Bracaglia: Monitoring and Treating Lung Disease in Still's Disease

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Presentation from Dr. Grant Schulert: Criteria to consider BMT

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Presentaton from Dr. Juliana Silva: Long Term outcomes of Allogeneic HSCT for severe, refractory Juvenile Idiopathic Arthritis

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Presentation from Dr. Jim Connelly: Immune Reconstitution after Bone Marrow Transplant

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Presentation from Dr. Rebecca Marsh: BMT: How does it work and when it can be considered?

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Patient perspective about BMT in SJIA: Presentation from Luciana Pereira

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International Perspective: Presentation from dr Bruno Fautrel: Treating Refractory Adult Still's Patients

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International Perspective: Presentation from Dr. Juan Manuel Mosquera, Spain: Refractory disease (Still’s +/- MAS)

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International perspectives (China): Presentation from Dr. Caifeng Li

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International perspectives (Brazil): Presentation from Dr. Maria Teresa Terreri

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Presentation from Dr. Nadrendra Bagri: International perspectives (India)

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Presentation from Dr. Fabrizzio de Benedeti: Clinical Trials in Still's Disease (sJIA/AOSD)

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Presentation from Dr. Alexei Grom: SJIA with relapsing MAS

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Presentation from Dr. Ed Behrens: Treatment Paterns and Outcomes in Patients with Macrophage Activation Syndrome Secondary to Still's Disease Treated with Emapalumab

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Presentation from Dr. Paul brogan: Systemic Juvenile Idiopathic Arthritis: resistant disease, UK experience

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Presentation from Dr. Grant Schulert: The Changing face of SJIA.

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Licensed via creative commons https://creativecommons.org/licenses/by/4.0/

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In this informative presentation, you will explore the components and functions of the digestive system, which is crucial for processing food and providing energy. Learn about the liver, stomach, intestines, and other parts, as well as the interconnected roles of the circulatory and excretory systems that support digestion.