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IL-18 testing in the diagnosis and management of Still’s disease: Game-changer or Red Herring?

IL-18 testing in the diagnosis and management of Still’s disease: Game-changer or Red Herring?

@SJIA_Foundation
@SJIA_Foundation
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2 weeks ago 81
Other #nextgen2024 #stillsdisease #curesjia #sjia

IL-18 testing in the diagnosis and management of Still’s disease: Game-changer or Red Herring?

@SJIA_Foundation2 weeks ago

IL-18 testing in the diagnosis and management of Still’s disease: Game-changer or Red Herring? …
1/13
Disclosures • Industry funded research • Site PI (completed): Novartis, AB2Bio • In-kind support…
2/13
IL-18 testing
3/13
A common clinical conundrum 6 mos prev healthy male - Born FT, no preg/perinatal issues - Presen…
4/13
5/13
Which is the Still’s Rash?
6/13
Still’ s FMF TRA PS HID S Kawasa ki CAP S ??? Stre p
7/13
Presentation continued EBV/CMV/Adeno/HHV 6 - PCR neg Perforin/GranyzmeB: elevated by % & MCF…
8/13
FUO with HLH • Prolonged viral syndrome • Still’s • Atypical KD • Autoinflammatory To ‘Ro…
9/13
FUO with HLH • Prolonged viral syndrome • Atypical KD • Autoinflammatory • Still’s • Monog…
10/13
OK, so it’s IL-18 = 128,000 Still’s pg/mL CXCL9 = 14,000 pg/mL sIL-2Ra = 2300 pg/mL Anakinr…
11/13
Flare upon GC wean Recheck IL-18 to determine: Fever, ferritin, LFTs don’t tolerate < 0.5 mg/…
12/13
Remission on medication Still’s MRD biomarkers • LDH/aldolase • D-dimer • Ferritin • sIL-2…
13/13


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