Biomarkers in Systemic Juvenile Idiopathic Arthritis, Macrophage Activation Syndrome and Their Importance in COVID Era

Biomarkers in Systemic Juvenile Idiopathic Arthritis, Macrophage Activation Syndrome and Their Importance in COVID Era

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Biomarkers in Systemic Juvenile Idiopathic Arthritis, Macrophage Activation Syndrome and Their Importance in COVID Era

@rashmi3 weeks ago

Citation: Ailioaie, L.M.; Ailioaie, C.;
Litscher, G. Biomarkers in Systemic
Juvenile Idiopathic A…

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At the same time, prolonged anti-inflammatory treatment …

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therapies and personalized interventions, improving dise…

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At the level of the innate immune system, inflammasomes …

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TRIM58, and KLF1 genes, while the green–yellow module wa…

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Table 1. Cont.
Reference/Year Predictive Effects in sJI…

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ILCs are deeply embedded lymphocytes in tissues that do …

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Due to the connection between IL-18 and the activity of …

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(NF-κB) p65 in NK cells after being boosted by in vitro …

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response. M2b macrophages secrete IL-1, IL-6, IL-10, an…

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found to have non-inflammatory disorders. The results i…

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2.2.4. Platelets
In 2016, a group of experts analyzed …

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Table 2. Cellular biomarkers proposed for the diagnosis…

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Table 2. Cont.
Reference/Year Cellular Biomarkers Pred…

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Table 2. Cont.
Reference/Year Cellular Biomarkers Pred…

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disease generally became inactive after 33 days, and af…

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sion of the cytokine IL-1β. The NLRP3 gene codifies the…

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involvement and platelet counts—but not during remissio…

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sJIA. The authors’ results contribute to a deeper under…

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a form of active cytokine to induce IFN-γ. IL-18 can be…

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motion some inflammatory mediators (e.g., adhesion mole…

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IL-18BP in patients with AOSD or sJIA with MAS has show…

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and endothelial cells. The results showed that plasma I…

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of the study showed that the concentrations of CXCL9, C…

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at their last visit, and 10/32 patients had a positive …

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Table 3. Important cytokines as biomarkers for the diag…

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Table 3. Cont.
Reference/Year Cytokines as Biomarkers …

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Table 3. Cont.
Reference/Year Cytokines as Biomarkers …

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Table 3. Cont.
Reference/Year Cytokines as Biomarkers …

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Table 3. Cont.
Reference/Year Cytokines as Biomarkers …

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Hinze et al. aimed to examine the associations of basel…

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2.3.10. Neopterin
In a recent study, Takakura et al. c…

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with data on the more accurate stratification of diseas…

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Because the differential diagnosis of sJIA from other i…

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2.3.13. sRAGE
Receptor for advanced glycation end prod…

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mucin-3 (TIM-3) are released during apoptosis or necros…

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authors proved the paradigm that the risk of severe dis…

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Ganeva et al. investigated biomarkers and their relatio…

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Leucine-rich α-2 glycoprotein 1 (LRG1) is an important …

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Table 4. Cont.
Reference/Year Chemokines and Other Bio…

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Table 4. Cont.
Reference/Year Chemokines and Other Bio…

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Table 4. Cont.
Reference/Year Chemokines and Other Bio…

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Table 4. Cont.
Reference/Year Chemokines and Other Bio…

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Table 4. Cont.
Reference/Year Chemokines and Other Bio…

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sJIA-MAS continues to be a major problem in pediatric r…

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Neopterin is released by macrophages stimulated by IFN-…

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There is no updated consensus regarding the validation,…

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Since the processes in sJIA-MAS take place extremely ra…

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CD Cluster of differentiation
CD163 Cluster of differe…

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IV Intravenous
JDM Juvenile dermatomyositis
JIA Juven…

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PRF1 Perforin 1
PBMC Peripheral blood mononuclear cell…

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References
1. Hinze, C.; Gohar, F.; Foell, D. Manageme…

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22. Canna, S.W.; de Jesus, A.A.; Gouni, S.; Brooks, S.R…

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46. Fukui, S.; Iwamoto, N.; Takatani, A.; Igawa, T.; Sh…

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69. Minoia, F.; Davì, S.; Horne, A.; Demirkaya, E.; Bov…

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93. Kostik, M.M.; Isupova, E.A.; Belozerov, K.; Likhach…

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116. Yasin, S.; Fall, N.; Brown, R.A.; Henderlight, M.;…

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140. Kwak, H.B.; Lee, S.W.; Jin, H.M.; Ha, H.; Lee, S.H…

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165. Altobelli, E.; Angeletti, P.M.; Petrocelli, R.; La…

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189. Paudel, Y.N.; Angelopoulou, E.; Piperi, C.; Balasu…

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211. Urushima, H.; Fujimoto, M.; Mishima, T.; Ohkawara,…

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Biomarkers in Systemic Juvenile Idiopathic Arthritis, Macrophage Activation Syndrome and Their Importance in COVID Era

@rashmi

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