DNA METHYLATION-BASED BIOMARKERS AND THE EPIGENETIC CLOCK THEORY OF AGEING.pdf

DNA METHYLATION-BASED BIOMARKERS AND THE EPIGENETIC CLOCK THEORY OF AGEING.pdf

@powderhownd1492

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Science

DNA METHYLATION-BASED BIOMARKERS AND THE EPIGENETIC CLOCK THEORY OF AGEING.pdf

@powderhownd14924 days ago

Since the 1980s, it has been recognized that valid
and reliable biomarkers of ageing will be need…

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ageing. We then discuss how accelerated epigenetic
age — that is, when estimated age is higher th…

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methylation levels (covariates) using a penalized regression model33. Similarly, Hannum et al. der…

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penalized regression model used a transformed version of chronological age as an outcome measure. …

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multiple sources of cells, tissues and organs (with the
exception of sperm) across the entire lif…

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whereas a negative value suggests that the tissue ages
slower than would be expected.
Intrinsic …

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example, carotenoid levels) and smoking status. By
contrast, DNAm age acceleration as determined …

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acceleration. These analyses produced fairly high heritability estimates (h2
) of approximately 4…

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for example, for measuring the number of cell divisions
incurred by long-lived adult stem cells32…

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of DNAm age is illustrated by its relation to gender:
boys are epigenetically older than girls at…

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processes underlying DNAm age are to a considerable
extent under genetic control. As such, it is …

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to high sequence conservation, the human multi-tissue
DNAm age estimator also applies to chimpanz…

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53. Li, Y. et al. The DNA methylome of human peripheral
blood mononuclear cells. PLoS Biol. 8, e1…

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135. Petkovich, D. A. et al. Using DNA Methylation profiling
to evaluate biological age and longe…

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DNA METHYLATION-BASED BIOMARKERS AND THE EPIGENETIC CLOCK THEORY OF AGEING.pdf

@powderhownd1492

This presentation explores the evolution of biomarkers associated with biological age, emphasizing DNA methylation's role in shaping our understanding of ageing. It discusses the establishment of epigenetic clocks, their predictive accuracy across tissues, and their implications for healthspan and lifespan interventions. The mechanisms and related cultural shifts in science are also examined.

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