NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 2

NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 2

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NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 2

@SJIA_Foundation2 weeks ago

BMT: How Does It Work and
When Can It Be Considered?
Rebecca Marsh, MD
Cincinnati Children’s Ho…

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Disclosures
• Employed part-time by Pharming Healthcare
• Advisory board or consulting - Amgen, A…

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I Failed to Find a Good
Rheumatology Joke to Open With…

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I Failed to Find a Good
Rheumatology Joke to Open With…
• They were all too inflammatory!

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BMT: How Does It Work?

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BMT: Terminology
• For today: Bone Marrow Transplant (BMT) = Hematopoietic Cell
Transplant (HCT)…

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Allogeneic BMT Process
• It is like planting a garden

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First you need to make room for a garden
The Garden

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Then you have to plant the seeds
The Garden

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Then you have to wait…
The Garden

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You have to nurture the new plants...
Water, Sun, Food, Love
keep harmful things away
The Garden

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… until they are
able to survive on their own
The Garden

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So, What If We Want To Plant Stem Cells
Instead of Flowers?

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Process
1) Patient
2) Donor
3) Conditioning
4) Graft (Stem Cells)
5) Recovery

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• Step 1: Patient
– Which patients are appropriate to consider for allogeneic BMT?
Allogeneic BMT…

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– #1: The disease needs to be
caused by a genetic disorder
(known or unknown) that only or
pr…

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A Lot to Balance!
Transplant
Risk
Immune
Disorder
Risk
Donor Options
Lung Disease
MAS Ne…

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Step 2: Find a Donor

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HLA Typing and Donor Search
commons.wikimedia.org/wiki/File:HLA.jpg

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HLA Typing and Donor Search
commons.wikimedia.org/wiki/File:HLA.jpg

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HLA Typing and Donor Search
commons.wikimedia.org/wiki/File:HLA.jpg

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HLA Typing and Donor Search
commons.wikimedia.org/wiki/File:HLA.jpg

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HLA Typing and Donor Search
commons.wikimedia.org/wiki/File:HLA.jpg https://www.aboutkidshealth.ca…

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HLA Typing and Donor Search
Patient
Donor

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Step 3: Conditioning Regimen
Vs. Vs..
CCHMC CHOP GOSH
Transplant Center Conditioning Regimens
S…

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Step 4a: Stem Cell Collection

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Step 4b: Stem Cell Infusion
• Infuse stem cell product into patient

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HLA Typing and Donor Search
commons.wikimedia.org/wiki/File:HLA.jpg

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Why do we care about HLA match?
GVHD
– Remains the
Biggest Barrier
to Successful
Outcomes
…

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NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 2

@SJIA_Foundation

Presentation from Dr. Rebecca Marsh: BMT: How does it work and when it can be considered?

Science

#sjiafoundation #sjia #bmt #curesjia

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