NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 2
Presentation from Dr. Rebecca Marsh: BMT: How does it work and when it can be considered?

































NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 2
- 1. BMT: How Does It Work and When Can It Be Considered? Rebecca Marsh, MD Cincinnati Children’s Hospital
- 2. Disclosures • Employed part-time by Pharming Healthcare • Advisory board or consulting - Amgen, AB2Bio, SOBI
- 3. I Failed to Find a Good Rheumatology Joke to Open With…
- 4. I Failed to Find a Good Rheumatology Joke to Open With… • They were all too inflammatory!
- 5. BMT: How Does It Work?
- 6. BMT: Terminology • For today: Bone Marrow Transplant (BMT) = Hematopoietic Cell Transplant (HCT) = Stem Cell Transplant etc Allogeneic Autologous Stem Cells Stem Cells
- 7. Allogeneic BMT Process • It is like planting a garden
- 8. First you need to make room for a garden The Garden
- 9. Then you have to plant the seeds The Garden
- 10. Then you have to wait… The Garden
- 11. You have to nurture the new plants... Water, Sun, Food, Love keep harmful things away The Garden
- 12. … until they are able to survive on their own The Garden
- 13. So, What If We Want To Plant Stem Cells Instead of Flowers?
- 14. Process 1) Patient 2) Donor 3) Conditioning 4) Graft (Stem Cells) 5) Recovery
- 15. • Step 1: Patient – Which patients are appropriate to consider for allogeneic BMT? Allogeneic BMT in IEI
- 16. – #1: The disease needs to be caused by a genetic disorder (known or unknown) that only or predominantly affects hematopoietic derived cells Ogonek et al, 2016 – #2: Patients should be at high risk of morbidity or mortality from their disease In General: 2 Requirements to Consider HCT Immune System
- 17. A Lot to Balance! Transplant Risk Immune Disorder Risk Donor Options Lung Disease MAS New Clinical Trial/ New Therapies Response to Therapies Co-Morbidities
- 18. Step 2: Find a Donor
- 19. HLA Typing and Donor Search commons.wikimedia.org/wiki/File:HLA.jpg
- 20. HLA Typing and Donor Search commons.wikimedia.org/wiki/File:HLA.jpg
- 21. HLA Typing and Donor Search commons.wikimedia.org/wiki/File:HLA.jpg
- 22. HLA Typing and Donor Search commons.wikimedia.org/wiki/File:HLA.jpg
- 23. HLA Typing and Donor Search commons.wikimedia.org/wiki/File:HLA.jpg https://www.aboutkidshealth.ca/article?contenti d=1555&language=english# GVHD
- 24. HLA Typing and Donor Search Patient Donor
- 26. Step 3: Conditioning Regimen Vs. Vs.. CCHMC CHOP GOSH Transplant Center Conditioning Regimens Serotherapy A Chemotherapy ABC Serotherapy B Chemotherapy BC Serotherapy A Chemotherapy BCD
- 27. Step 4a: Stem Cell Collection
- 28. Step 4b: Stem Cell Infusion • Infuse stem cell product into patient
- 29. Step 5
- 30. Thank you!
- 31. 14 7 1 year
- 32. HLA Typing and Donor Search commons.wikimedia.org/wiki/File:HLA.jpg
- 33. Why do we care about HLA match? GVHD – Remains the Biggest Barrier to Successful Outcomes https://www.aboutkidshealth.ca/article?contentid=1555&language=english#