NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 3

@SJIA_Foundation

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Science #sjiafoundation #sjia #bmt #curesjia

NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 3

@SJIA_Foundation2 weeks ago

Immune Reconstitution
after Bone Marrow
Transplant
NextGen Therapies in SJIA, Still’s & MAS Co…

1/10

Immune
Recovery
after BMT
Stern et al. Frontiers in Immunology 2018; 9:1672

2/10

Measures of Immune Reconstitution (IR)
• Immune cell phenotyping
o Focus in BMT has been on T (tr…

3/10

Measures of Immune Reconstitution (IR)
•Transcriptome (gene expression through RNA analysis)
o Ad…

4/10

Measures of Immune Reconstitution (IR)
• Chimerism (donor versus recipient)
o Advantages: Predict…

5/10

Importance of T-cell (CD4+),
B-cell Recovery
Non-Relapse Mortality (NRM) and chronic (c)GVHD bas…

6/10

Immune Recovery in JIA
Early IR (D+0-D+100): Antigen driven and
homeostatic proliferation
Late …

7/10

Impact of Chimerism on BMT Outcomes in
JIA
Silva et al. Blood Advances 2018; 2:7

8/10

Macrophage (rheuMatologist) Cell
Murine Alveolar Macrophage (AM) Recovery after
Congenic BMT wit…

9/10

Summary of BMT and JIA BMT IR
• Multiple ways to evaluate immune recovery and reconstitution
and…

10/10

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NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 3

@SJIA_Foundation

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NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 3