NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 4

@SJIA_Foundation

8 Followers

2 weeks ago 73

Science #sjiafoundation #sjia #bmt #curesjia

NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 4

@SJIA_Foundation2 weeks ago

$Long Term outcomes of Allogeneic HSCT for severe, refractory Juvenile Idiopathic Arthritis Jul…$

1/14

Allo-HSCT for JIA
• Most common cancer in children & most common cause of death
< 20 years of ag…

2/14

Results
• 12/16 (75%) patients achieved
CR;
• 2/16 patients died of transplant
related toxici…

3/14

LTFU UPDATED COHORT
N. centers 9
N. patients 31
Period 2007 - 2022
Type of JIA
• Polyarthritis…

4/14

HSCT CHARACTERISTICS
HLA matching
10/10 MSD 6/31 (19%)
10/10 MUD 18/31 (58%)
9/10 MMUD 5/31 (16…

5/14

LONG TERM RESULTS
N=31
24/26
CR
1/26
PR
5/31
Died
14/31
CR
1/2
Relapsed
/
Active
d…

6/14

CAUSES OF DEATH
1 Fungal chest infection D+85

1 RSV pneumonitis D+28
2 Thrombotic microang…

7/14

RELAPSE/REMISSION
Patient JIA
subtype
Time to
relapse
Type of
relapse
Chimerism
at relap…

8/14

RELAPSE/ ACTIVE DISEASE
Patient JIA
subtype
Time to
relapse
Type of relapse Chimerism at
re…

9/14

Survival Outcomes
6y OS: 84%
• Deaths within first 18 m
CR: 19/26 (61%) at last FU
PR: 1/26 (4…

10/14

$In summary •Allogeneic HSCT is an alternative option for patients with refractory and/or complic…$

11/14

Future perspectives
• Consensus Statement on indications and timing for transplant
• Prospective…

12/14

Acknowledgements
Teaching Hospital
Motol, Prague
Petr Sedlacek
Renata Formankova
GOSH
Persi…

13/14

14/14

↑ Previous
↓ Next
f Fullscreen
esc Exit Fullscreen

Related Jaunts

BMT in SJIA patients

@lucianapapaleo

1 month ago • 135 views

NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 5

@SJIA_Foundation

2 weeks ago • 70 views

NextGen 2024: Monitoring &Treating Lung Disease in SJIA Session Part 2

@SJIA_Foundation

2 weeks ago • 102 views

$NextGen 2024: Refractory SJIA & MAS Session Part 2$

NextGen 2024: Refractory SJIA & MAS Session Part 2

@SJIA_Foundation

2 weeks ago • 63 views

NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 1

@SJIA_Foundation

2 weeks ago • 347 views

NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 2

@SJIA_Foundation

2 weeks ago • 77 views

$NextGen 2024: Refractory SJIA & MAS Session Part 4$

NextGen 2024: Refractory SJIA & MAS Session Part 4

@SJIA_Foundation

2 weeks ago • 73 views

NextGen 2024: Weaning meds when disease is controlled Session Part 2

@SJIA_Foundation

2 weeks ago • 167 views

$NextGen 2024: Refractory SJIA & MAS Session Part 6$

NextGen 2024: Refractory SJIA & MAS Session Part 6

@SJIA_Foundation

2 weeks ago • 73 views

NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 3

@SJIA_Foundation

2 weeks ago • 79 views

NextGen 2024: Monitoring &Treating Lung Disease in SJIA Session Part 1

@SJIA_Foundation

2 weeks ago • 103 views

NextGen 2024: Genetics in SJIA Session Part 2

@SJIA_Foundation

2 weeks ago • 90 views

NextGen 2024: Genetics in SJIA Session Part 3

@SJIA_Foundation

2 weeks ago • 408 views

IL-18 testing in the diagnosis and management of Still’s disease: Game-changer or Red Herring?

@SJIA_Foundation

2 weeks ago • 80 views

NextGen 2024: Genetics in SJIA Session Part 1

@SJIA_Foundation

2 weeks ago • 89 views

More from author

NextGen 2024: Weaning meds when disease is controlled Session Part 2

@SJIA_Foundation

2 weeks ago • 167 views

NextGen 2024: Weaning meds when disease is controlled Session Part 1

@SJIA_Foundation

2 weeks ago • 101 views

NextGen 2024: Genetics in SJIA Session Part 3

@SJIA_Foundation

2 weeks ago • 408 views

NextGen 2024: Genetics in SJIA Session Part 2

@SJIA_Foundation

2 weeks ago • 90 views

NextGen 2024: Genetics in SJIA Session Part 1

@SJIA_Foundation

2 weeks ago • 89 views

NextGen 2024: Monitoring &Treating Lung Disease in SJIA Session Part 2

@SJIA_Foundation

2 weeks ago • 102 views

NextGen 2024: Monitoring &Treating Lung Disease in SJIA Session Part 1

@SJIA_Foundation

2 weeks ago • 103 views

NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 5

@SJIA_Foundation

2 weeks ago • 70 views

NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 3

@SJIA_Foundation

2 weeks ago • 79 views

NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 2

@SJIA_Foundation

2 weeks ago • 77 views

NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 1

@SJIA_Foundation

2 weeks ago • 347 views

$NextGen 2024: Refractory SJIA & MAS Session Part 8$

NextGen 2024: Refractory SJIA & MAS Session Part 8

@SJIA_Foundation

2 weeks ago • 66 views

$NextGen 2024: Refractory SJIA & MAS Session Part 7$

NextGen 2024: Refractory SJIA & MAS Session Part 7

@SJIA_Foundation

2 weeks ago • 52 views

$NextGen 2024: Refractory SJIA & MAS Session Part 6$

NextGen 2024: Refractory SJIA & MAS Session Part 6

@SJIA_Foundation

2 weeks ago • 73 views

$NextGen 2024: Refractory SJIA & MAS Session Part 5$

NextGen 2024: Refractory SJIA & MAS Session Part 5

@SJIA_Foundation

2 weeks ago • 64 views

Browse Jaunts

Help

Social

Legal

NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 4

@SJIA_Foundation

8 Followers

NextGen 2024: Bone Marrow Transplantation (BMT) Session Part 4