NextGen 2024: Genetics in SJIA Session Part 3

NextGen 2024: Genetics in SJIA Session Part 3

@SJIA_Foundation

8 Followers

2 weeks ago 409

Science #stillsdisease #sjiafoundation #sjia #genetics #curesjia

NextGen 2024: Genetics in SJIA Session Part 3

@SJIA_Foundation2 weeks ago

What is the role of
HLA-DRB1*15 in Still’s
disease
Michael Ombrello
Translational Genetics an…

1/20

DISCLOSURES
•No conflicts of interest

2/20

WHAT ARE HUMAN LEUKOCYTE
ANTIGEN (HLA) PROTEINS?

3/20

WHAT ARE HUMAN LEUKOCYTE ANTIGEN
(HLA) PROTEINS?
A family of proteins expressed on the surface of…

4/20

WHAT IS HLA-DRB1*15?

5/20

WHAT IS HLA-DRB1*15?
• A common class II HLA allele group
• IE. HLA-DRB1*15:01, *15:02, *15:03, e…

6/20

WHAT IS THE RELATIONSHIP BETWEEN
HLA-DRB1*15 AND SYSTEMIC
JIA?

7/20

HLA-DRB1*15 ALLELES ARE NOT
ASSOCIATED WITH SJIA
Ombrello MJ et al, 2015 (PMID 26598658)
9 indep…

8/20

HLA-DRB1*15 DOES NOT ASSOCIATE
WITH SJIA IN IMMUNOCHIP STUDY
Unpublished Data
Both of these stud…

9/20

HLA-DRB1*15 CARRIAGE VARIES BY
GEOGRAPHY AND ANCESTRY
• HLA-DRB1*15 carriage rates
• Myanmar 41-…

10/20

WHAT IS THE RELATIONSHIP BETWEEN
HLA-DRB1*15 AND STILL’S-LUNG
DISEASE?

11/20

STILL’S-LUNG DISEASE IS ASSOCIATED WITH
HLA-DRB1*15 ALLELES
1. Still’s-LD carriage of HLA-DRB1*15…

12/20

3
6
1 0
0
7 3
Lerman 2023
Drug reaction
Lung disease
HLA-DRB1*15+
All negative
3
1
5
1…

13/20

WHAT IS THE RELATIONSHIP BETWEEN
HLA-DRB1*15 AND DRUG
REACTIONS?

14/20

DRUG REACTIONS IN STILL’S DISEASE ASSOCIATE
WITH HLA-DRB1*15 ALLELES
1. Drug reaction carriage of…

15/20

HLA-DRB1*15 in drug reaction (surrogate): 78/92 (84.8%)
3
6
1 0
0
7 3
Lerman 2023
Drug react…

16/20

WHAT CONNECTS HLA-DRB1*15 WITH
DRUG REACTION/LD?
•Coexistant LD and drug reaction with shared HLA…

17/20

WHAT CONNECTS HLA-DRB1*15 WITH
DRUG REACTION/LD?
1. Antigen dependent
• MHC presentation of alte…

18/20

Still’s disease!

19/20

Acknowledgements
Translational Genetics and Genomics Section, NIAMS
Hiroto Nakano, MD PhD
Mari…

20/20

@SJIA_Foundation

Drag Me

Comments 0 Info

NextGen 2024: Genetics in SJIA Session Part 3

@SJIA_Foundation

Presentation from Dr. Michael Ombrello: What is the role of HLA DRB1*15 in Still's disease

Science

#stillsdisease #sjiafoundation #sjia #genetics #curesjia

This website uses cookies to improve your experience. By using this site, you consent to the use of cookies.