NextGen 2024: Refractory SJIA & MAS Session Part 1

NextGen 2024: Refractory SJIA & MAS Session Part 1

@SJIA_Foundation

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Science #sjiafoundation #curesjia #stillsdisease #sjia

NextGen 2024: Refractory SJIA & MAS Session Part 1

@SJIA_Foundation2 weeks ago

The changing face of SJIA
Grant Schulert, MD PhD
Associate Professor of Pediatrics
Division of R…

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$Complicated or refractory SJIA • Outcomes for children with SJIA have markedly improved with intro…$

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$Defining refractory SJIA • Refractory SJIA (broadly) – Failure to respond to IL-1 AND IL-6 bloc…$

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$Defining refractory SJIA • “Persistent partial MAS” – A patient with active SJIA and persistent…$

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$What is refractory SJIA biologically? • Most severe patients (correct treatments but strong not en…$

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$New refractory courses - IBD • Anecdotally – also increasing • Case series lead by Betsy Mellins …$

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$New refractory courses – lung disease • “SJIA-LD” likely encompasses several disease phenotypes (s…$

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Might “SJIA-LD” be a distinct phenotype of the
disorders classified as “SJIA”??
• Much younger a…

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Atypical rashes in systemic JIA - definitely bad
but maybe not always DRESS?
• 30 patients with …

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$What about HLA-DRB1*15? Could this be marker for refractory disease phenotypes? • How common is …$

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NextGen 2024: Refractory SJIA & MAS Session Part 1

@SJIA_Foundation

Presentation from Dr. Grant Schulert: The Changing face of SJIA.

Science

#sjiafoundation #curesjia #stillsdisease #sjia

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