NextGen 2024: Refractory SJIA & MAS Session Part 4

NextGen 2024: Refractory SJIA & MAS Session Part 4

@SJIA_Foundation
@SJIA_Foundation
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2 weeks ago 74

NextGen 2024: Refractory SJIA & MAS Session Part 4

@SJIA_Foundation2 weeks ago

SJIA and MAS; experience from apex tertiary care 
referral Institution of India 
Narendra Bagri 
…
1/23
Next Gen conference,Washington DC 
Division of Rheumatology, Department of Pediatrics, AIIMS, New …
2/23
Next Gen conference,Washington DC 
Division of Rheumatology, Department of Pediatrics, AIIMS, New …
3/23
Next Gen conference,Washington DC 
Division of Rheumatology, Department of Pediatrics, AIIMS, New …
4/23
Next Gen conference,Washington DC 
Division of Rheumatology, Department of Pediatrics, AIIMS, New …
5/23
Next Gen conference,Washington DC 
Division of Rheumatology, Department of Pediatrics, AIIMS, New …
6/23
Next Gen conference,Washington DC 
Division of Rheumatology, Department of Pediatrics, AIIMS, New …
7/23
Next Gen conference,Washington DC 
Division of Rheumatology, Department of Pediatrics, AIIMS, New …
8/23
Next Gen conference,Washington DC 
Division of Rheumatology, Department of Pediatrics, AIIMS, New …
9/23
Week 1 2 3 4 
Ferritin 
(ng/mL)
Cell counts
TLC (/ mm3)
Platelet count 
(lakhs/mm3)
Tachypne…
10/23
Next Gen conference,Washington DC 
Division of Rheumatology, Department of Pediatrics, AIIMS, New …
11/23
Case vigette 
14-yr-old girl
Symptomatic since 10 years of age 
History of multiple blood transf…
12/23
Course
Managemen
t
Symptomatolog
y
Room air 
Orally allowed 
Ceftriaxone
O2
Fever
Respira…
13/23
Course in HDU 
Managemen
t
Symptomatolog
y
HHHFNC
Piperacillin tazobactam/teicoplanin/septran…
14/23
Managemen
t Symptomatolog
y
VC SIMV
Piptaz/teIcoplanin
Septran
Valganciclovir
Lipo amphoteri…
15/23
Thoughts …
•Biomarkers to differentiate infection versus MAS : IL-18 ?
•PLEX in MAS
16/23
Next Gen conference,Washington DC 
Division of Rheumatology, Department of Pediatrics, AIIMS, New …
17/23
Next Gen conference,Washington DC 
Division of Rheumatology, Department of Pediatrics, AIIMS, New …
18/23
Next Gen conference,Washington DC 
Division of Rheumatology, Department of Pediatrics, AIIMS, New …
19/23
Next Gen conference,Washington DC 
Division of Rheumatology, Department of Pediatrics, AIIMS, New …
20/23
Thoughts ? 
• Trisomy 21 and SJIA and MAS 
• Etoposide 
• JAK -i
21/23
Next Gen conference,Washington DC 
Division of Rheumatology, Department of Pediatrics, AIIMS, New …
22/23
Next Gen conference,Washington DC 
Division of Rheumatology, Department of Pediatrics, AIIMS, New …
23/23


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