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NextGen 2024: Unmet Needs & Clinical Trial Challenges Session Part 1

NextGen 2024: Unmet Needs & Clinical Trial Challenges Session Part 1

@SJIA_Foundation
@SJIA_Foundation
8 Followers
2 weeks ago 72
Science #macrophageactivation #sjiafoundation #sjia #stillsdisease #curesjia

NextGen 2024: Unmet Needs & Clinical Trial Challenges Session Part 1

@SJIA_Foundation2 weeks ago

SJIA with relapsing MAS Alexei Grom, MD Cincinnati Children's Hospital Medical Center NextGen Th…
1/11
SJIA with refractory course • Despite recently approved IL-1 and IL-6 blocking agents, about 20% …
2/11
sJIA sJIA MAS sJIA sJIA MAS sJIA MAS MAS MAS Classic MAS MAS at sJIA onset “relapsing” …
3/11
SJIA patients with relapsing MAS • These patients appear at risk for sJIA-associated lung disease …
4/11
SJIA with relapsing MAS with Predominantly Liver Involvement • Persistently elevated liver enzym…
5/11
CD68+ macrophage s TNFα IL-6 IFNγ Liver Biopsy in MAS/sJIA CD8+ T lymphocytes Republished…
6/11
CD68+ macrophages Liver Biopsy in MAS/sJIA CD8+ T cells TNFα IL-6 IFNγ Republished with permi…
7/11
Liver biopsy: CD163 staining in SJIA Elevated Ast/Alt, + lab features of subclinical MAS Elevat…
8/11
MAS with Predominantly Liver Involvement • Similar histologic pattern observed by Prencipe et al. …
9/11
MAS with Predominantly Liver Involvement •JAKi? • CyA? • MMF? • Emapalumab?
10/11
Challenges with clinical trials in ‘smoldering MAS” • Do not fully meet criteria for MAS • Not el…
11/11


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