Neuroplacticity and Psychedelics

Neuroplacticity and Psychedelics

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2 weeks ago 48

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Neuroplacticity and Psychedelics

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Neuroplasticity and Psychedelics:
A comprehensive examination of classic and non-classic compou…

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Abstract
Neuroplasticity, the ability of the nervous system to adapt throughout an organism's l…

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“And one finds oneself, to put it all in perspective, in a situation where fifty different onoma…

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There is growing evidence of defective neuroplasticity in illnesses where psychedelics have show…

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Recently, the word "psychoplastogens" has been coined to describe substances that cause rapid an…

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phospholipase A2 (PLA), releasing arachidonic acid (AA) and modulating gene expression. Classic …

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Figure 1: The acute cellular mechanism of classic psychedelics, ketamine and MDMA.
3. Structura…

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(i.e., synaptic pruning) (Bernardinelli et al., 2014; Götz and Huttner, 2005). Neuritogenesis is…

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In vitro, treatment of animal-derived brain tissue with ketamine has been found to affect struct…

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3.1.2. Human
In human studies, direct evidence for the effect of ketamine on structural plasti…

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3.2.1. Preclinical
Classic psychedelics have been shown to upregulate structural plasticity in…

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In vivo, a single intracerebral injection of a low concentration of 5-MeO-DMT increased neural …

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cortex (ACC) (Bouso et al., 2015). In a report currently under review, Lyons and colleagues sho…

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plasticity such as synaptic scaling and spontaneous neurotransmitter release. Homeostatic plast…

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Importantly, this enhancement outlives the timescale of short-term adaptation, with post-tetanu…

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CA1 synapses after ketamine was found to be increased at 3 hours with theta-burst stimulation b…

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MDD measured 3-4 hours after drug administration. They found that the P2 component of the ERP w…

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were dependent on 5-HT2AR-mediated signalling. Also, the meta-plastic increase in LTD induced b…

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derived neurotrophic factor (BDNF), ERKs, and post-synaptic density proteins (PSD) (Ehrlich and…

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following a single ketamine infusion in bipolar patients (Rybakowski et al., 2013). Many studie…

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6 hours after drug intake in healthy volunteers (Holze et al., 2021; Hutten et al., 2021). Othe…

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Figure 3: Post-acute neuroplastic effects of psychedelics. Only the findings relative to the ne…

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whereas for the classic psychedelics, the activity of 5-HT2ARs seems to be required (Figure 1).…

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In humans, translating the evidence on neuroplasticity induced by psychedelics has proven to be…

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The authors declare that no specific funding was received for preparing this manuscript.
Decla…

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Ball, K.T., Wellman, C.L., Fortenberry, E., Rebec, G.V., 2009. Sensitizing Regimens of MDMA (Ec…

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kinase B from inhibitory control without reducing perineuronal nets enwrapping
parvalbumin in…

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Cohen, E.J., Quarta, E., Bravi, R., Granato, A., Minciacchi, D., 2017. Neural plasticity and ne…

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Dudek, S.M., Bear, M.F., 1992. Homosynaptic long-term depression in area CA1 of hippocampus and…

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Garrido, M.I., Kilner, J.M., Kiebel, S.J., Stephan, K.E., Baldeweg, T., Friston, K.J., 2009a. R…

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depression with suicidal thoughts: A pilot midazolam-controlled randomized clinical trial.
Bi…

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Ilchibaeva, T., Tsybko, A., Zeug, A., Müller, F.E., Guseva, D., Bischoff, S., Ponimaskin, E., N…

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Kopelman, J., Keller, T.A., Panny, B., Griffo, A., Degutis, M., Spotts, C., Cruz, N., Bell, E.,…

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in Prefrontal Cortex. Biol. Psychiatry 71, 996–1005.
https://doi.org/10.1016/j.biopsych.2011.…

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May, A., 2011. Experience-dependent structural plasticity in the adult human brain. Trends Cogn…

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Mouri, A., Noda, Y., Niwa, M., Matsumoto, Y., Mamiya, T., Nitta, A., Yamada, K., Furukawa, S., …

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Emission Tomographic Imaging Study of Synaptic Vesicle Glycoprotein 2A. Biol. Psychiatry.
htt…

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Salami, M., Fathollahi, Y., Esteky, H., Motamedi, F., Atapour, N., 2000. Effects of ketamine on…

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Visual Sensory Evoked Potential Long-term Potentiation in Patients With Major Depressive
Diso…

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comprehensive systematic review. BJPsych Open 8, e19.
https://doi.org/10.1192/bjo.2021.1061
…

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Zhang, Z., Zhang, JiFeng, Li, J., Zhang, Jiaqi, Chen, L., Li, Y., Guo, G., 2020. Ketamine Regul…

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Neuroplacticity and Psychedelics

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